(AP) Penn State football coach James Franklin announced Tuesday that senior safety Ryan Keiser and senior running back Zach Zwinak will miss the remainder of the season with injuries.

Keiser, a co-captain, was injured last Thursday in practice. Zwinak sustained an injury on the opening kickoff against Ohio State.Keiser started the initial six games of the season at free safety. Before last week's game, he was No. 3 on the team with 25 tackles (17 solo), had the game-clinching interception at Rutgers and two pass break-ups.Zwinak finishes his career 15th on the Penn State career rushing list with 2,108 yards. Having played in all 31 games the past three seasons, he is tied for 10th on the school list with 11 career 100-yard rushing games, eight of which came in November games the past two years. He scored 18 career rushing touchdowns, including 12 last season, and started 12 career games.Zwinak became the 14th different Nittany Lion (22 times) to rush for 1,000 yards in a season in 2012, finishing with exactly 1,000 yards after gaining a career-high 179 yards in the senior day overtime win against Wisconsin.