PHILADELPHIA (AP) - Of all the high-profile players making debuts in a new uniform, Eagles cornerback Ronald Darby was the most impressive.

Darby intercepted former teammate Tyrod Taylor's pass and returned it 48 yards and also broke up two passes in his first game since Philadelphia acquired him from Buffalo last week, and the Eagles beat the Bills 20-16 on Thursday night."They were running a lot of routes that looked similar, so I was being patient with everything and cutting them off," Darby said.Alshon Jeffery, a former Pro Bowl wide receiver signed by the Eagles in the offseason, caught his first pass from Carson Wentz and finished with two receptions for 23 yards.Bills cornerback E.J. Gaines also had an interception in his first game since coming from the Rams in a trade last week. Gaines picked third-string quarterback Matt McGloin, who has struggled in two preseason games.Wideout Anquan Boldin, a three-time Pro Bowl pick recently signed by the Bills, caught one pass for 5 yards.The Eagles traded wide receiver Jordan Matthews and a 2018 third-round pick for Darby. Matthews, a popular player in Philadelphia's locker room, didn't make the trip because of a chest injury.Both teams looked sloppy in a mistake-filled game. There were 23 penalties and seven turnovers, including Mitchell White's interception in the end zone on the final play to secure the win."One hundred percent unacceptable," Bills coach Sean McDermott said. "Good teams don't beat themselves."Wentz completed 6 of 9 passes for 56 yards. Taylor was 8 of 18 for 53 yards and two interceptions.After T.J. Yates tossed a 9-yard touchdown pass to Brandon Reilly late in the fourth quarter to give the Bills a 16-13 lead, Philadelphia's Byron Marshall ran in from the 1 for the go-ahead score.McGloin finished 12 of 20 for 131 yards and one interception for the Eagles. He took most of the snaps because backup Nick Foles remains sidelined.Eagles LB Mychal Kendricks had a sack, interception and tackle for loss. Kendricks had asked for a trade in the offseason, but he's slated to be the starter at the outside spot.Eagles rookie defensive end Derek Barnett, the 14th overall pick, had another sack after getting two in the preseason opener.