Paul Reiser will do the thing he enjoys most in his career when he brings his stand-up comedy to Stroudsburg’s Sherman Theater, Main Street, on Nov. 13.

“When I was a kid, I was an aficionado of stand-up, but never knew you could do it,” said the New York City-born comedian, actor and writer. “It’s like playing for the Yankees. You gotta be selected. You gotta be outstanding.

“Comedy clubs we know of now were starting to come into being in the ’70s, when I was in college. I saw a path. You go to these couple places in the city, it somehow turns you into a comedian. I don’t know if I would have figured out how to do it. It was an inviting, accessible path.”

Reiser, also an author and musician, “started seeing guys on TV; Freddie Prinze, Gabe Kaplan, Jimmie Walker, Richard Pryor to an extent. I was 18. I went up on audition night to Catch a Rising Star. I did five minutes. I may have gotten one laugh, maybe two.”

The good thing about being that green, he added, “is you’re protected by a veil of ignorance, like a baby in an embryo, in a sack, protected from things that could harm you. You don’t know how good you are. I loved the feeling. I couldn’t wait to do it again.”

In stand-up, “everybody has their own tastes, standards,” Reiser said. “There are things I don’t do that other people do great. It takes a long time to figure out what your lane is, what you are drawn to.”

For Resier, “it’s been pretty consistent. In the beginning, you’re flying, reaching for any joke you can. In the late 1980s, when I had just gotten married, or before, I started talking about real stuff that was happening. Living with a woman, being married, changes. It felt more organic, true. This is what I do.”

Such stand-up led to the birth of “Mad About You,” the 1992-1999 sitcom for which Reiser earned six Emmy nods for his work as Paul Buchman. Resier, who co-created the series and co-wrote theme song “The Final Frontier,” starred opposite Helen Hunt. The twosome returned for a series revival in 2019.

“I was approached about doing a show,” he said. “I wanted it to be small in scope, a look at the silliness and craziness that goes on behind closed doors. That’s still where my brain goes. It’s what I find funny.”

The nicest compliments about “Mad About You,” Reiser said, were “‘You must have microphones in the house. It sounds like what we talked about yesterday.’ I get that with my stand-up.”

Reiser — whose comedic influences include George Carlin, Robert Klein and Mel Brooks — always tells people “I’m not smart enough to make anything up. I’m just going to tell you what happens in my house. Hopefully, you find it’s not just you.”

The comic, who did not perform stand-up from 1990 to 2010 or so, released his first stand-up special in 30-plus years, “Life, Death & Rice Pudding,” in 2024. He may do another special at the end of 2026.

While a music major at the State University of New York at Binghamton, Reiser appeared in “silly, unofficial” dorms-staged works. By accident, he landed his first film role when accompanying a friend to an audition: fast-talking and sarcastic Modell in Barry Levinson’s 1982 comedy-drama “Diner.”

The script, Reiser said, “had the MGM lion on the cover. I thought, ‘This looks like official show business. This is real.’ I only had three to four lines in the script. It’s basically all improv.”

After “Diner,” Reiser played Jeffrey Friedman in 1984’s “Beverly Hills Cop” — reprising the role in the franchise’s 1987 and 2024 sequels — and villain Carter Burke in sci-fi action thriller “Aliens.”

Burke returned in the 2024 Marvel comic “Aliens: What If …?” Reiser’s son Leon co-wrote the series with “The Goldbergs” creator Adam F. Goldberg and others, with Reiser offering some input.

Other projects have kept Reiser, a Los Angeles resident, busy. They include two Netflix series: “Long Story Short,” an adult animated comedy, and upcoming crime/workplace drama series “The Altruists.”

Also on tap, Reiser returns as Dr. Sam Owens and The Legend in the fifth and final seasons of Netflix’s “Stranger Things,” premiering Nov. 26, and Amazon Prime Video’s “The Boys,” respectively.

While Reiser sometimes finds it “fun to play in somebody else’s sandbox, when you get to create something, that’s really fun.” As examples, Reiser cited “Mad About You” and two of his films.

Reiser, wanting to work with “Columbo” star Peter Falk, wrote 2005’s “The Thing About My Folks.” The actor always loved Falk, who “reminded me of my dad. He played my father. That was joyful.”

Another “sweet experience” for Resier came with 2023’s “The Problem With People.” The writer fulfilled his fantasy of making a movie in Ireland, with which he fell in love upon visiting years prior.

Resier co-wrote his latest creation, a comedy script, with Leon and Goldberg. Reiser would star in the Fox multi-camera vehicle, in which a son works with his father in the damaged-goods business.

“Forty years ago, my dad had a wholesale foods business,” Reiser said, adding that he was predestined for the unglamorous gig had he not taken another path.

At this point, what does Reiser — who scored a 2021 supporting-actor Emmy nod for the Netflix comedy-drama “The Kominsky Method” — want to accomplish?

“To do nothing, stay still for a while. I keep aiming for nothing. I get distracted. I understand that’s the fun thing to do.”