Blood clots, a low platelet count, and damaged red blood cells cause the signs and symptoms of thrombotic thrombocytopenic purpura (TTP).

The signs and symptoms include:

Ÿ Purplish bruises on the skin or mucous membranes (such as on the mouth) due to bleeding under the skin. These bruises are called purpura.

Ÿ Pinpoint-sized red or purple dots on the skin that often are found in groups and may look like a rash. The spots, called petechiae, are due to bleeding under the skin.

Ÿ Paleness or jaundice (a yellowish color of the skin or whites of the eyes).

Ÿ Fatigue (feeling very tired and weak).

Ÿ Fever.

Ÿ A fast heart rate or shortness of breath.

Ÿ Headache, speech changes, confusion, coma, stroke, or seizure.

Ÿ A low amount of urine, or protein or blood in the urine.

Source: National Institutes of Health