Blood clots, a low platelet count, and damaged red blood cells cause the signs and symptoms of thrombotic thrombocytopenic purpura (TTP).

The signs and symptoms include:• Purplish bruises on the skin or mucous membranes (such as on the mouth) due to bleeding under the skin. These bruises are called purpura.• Pinpoint-sized red or purple dots on the skin that often are found in groups and may look like a rash. The spots, called petechiae, are due to bleeding under the skin.• Paleness or jaundice (a yellowish color of the skin or whites of the eyes).• Fatigue (feeling very tired and weak).• Fever.• A fast heart rate or shortness of breath.• Headache, speech changes, confusion, coma, stroke, or seizure.• A low amount of urine, or protein or blood in the urine.Source: National Institutes of Health